Endocrine Abstracts

In mammals, the gonads and the brain develop from bipotential organs that will differentiate into female or male organs, during a critical period of development. This process begins with the production of testosterone by the testes, which will be converted into estradiol in the brain, by the aromatase. While the end is defined by the moment when the inhibition of androgens (in males), or treatment with estrogens (in females), stops having an effect on brain dimorphism. But in ...

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has generate a pandemic disease around the world. It has been documented that diabetes mellitus (DM) acts as a risk factor among people hospitalized with coronavirus disease (COVID-19). The objective of this study is to test if DM may unfavorably influence the outcome of COVID-19.MethodsData from Hospital Universitario Central ...

Influence of Diabesity in the visceral adipose tissue miRNA expression profile.Background: The term diabesity arose in 2001 to refer to the coexistence of obesity (OB) and type 2 diabetes (T2D). It is estimated that 89% of adults diagnosed with T2D have a BMI greater than 25 kg/m2, and of them, 45% are obese. However, the mechanisms because why some obese patients develop T2D and other do not, are still unclear.Objective...

Background: the treatment of individuals with type 1 diabetes (T1D) has significantly evolved in recent years. Therefore, with the aim of achieving glycaemic targets to prevent or slow down the progression of the disease and its complications, hybrid closed-loop systems (AID) have been developed. These systems integrate three components: a continuous real-time glucose monitor, a control algorithm and an insulin pump. The objective of this study is to analyse the glycaemic and ...

Introduction: Paragangliomas (PGLs) are rare neuroendocrine tumors that arise from sympathetic or parasympathetic extra-adrenal paraganglia. PGLs have an extremely variable clinical presentation, depending on the localization, tumor size, catecholamine production, compressive symptoms, etc. Germline mutations in PGLs are associated in 30-35% of patients. Mutation in genes encoding the subunits of succinate dehydrogenase (SDH) leads to an increased risk of metastasis, specially...

Introduction: Pituitary adenomas are neoplasms originating in the pituitary gland. They represent 15.5% of tumor pathology of the central nervous system and their incidence is estimated at 3.4 cases per 100,000 inhabitants/year.Objective: To evaluate the postoperative results of adenomas operated on at the Hospital Clinico de Valladolid (HCUV) Material and Methods: Observational, transversal and retrospective study of operated aden...

CNB is increasingly being used as a diagnostic test for thyroid nodules with an inadequate (Bethesda 1) or indeterminate (Bethesda 3 and 4) FNAC results, which can account for up to 30% of the samples in some studies. CNB, using larger specimens and histological sections rather than cytological samples, allows better definition. We propose a simplified four-tiered classification of CNB specimens instead of the Bethesda system and evaluate its efficiency compared to definitive ...

Introduction: Diabetes mellitus secondary to exocrine pancreas diseases (pancreatogenic DM) has an unknown incidence and is considered underdiagnosed. Our objective was to evaluate the glycemic control parameters in patients with pancreatogenic DM who started Flash glucose monitoring (FGM).Methods: Prospective, observational study in a Spanish hospital. Patients with pancreatogenic DM who started FGM from January 2021 to August 2022 were recruited. Patie...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

Introduction: Detransition is the act of stopping or reversing a gender medical, social or surgical transition. The study’s purpose was to describe our experience with a group of transsexual people in detransition phase.Material and methods: A cohort of 204 people with gender incongruence attending the Identity Gender Unit Hospital Clinico of Valladolid from January 2014 to December 2022 was studied. Seven of those participants detransitioned and we...